Biodegradable Pla/Ha Composite Material Production and Mechanical Characterization for Temporary Implant Applications

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Published Dec 15, 2023
https://doi.org/10.56158/jpte.2023.59.2.02
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Vol. 2 No. 02 (2023): December

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Talip Çelik
Department of Biomedical Engineering, Kocaeli University, Kocaeli, Türkiye
https://orcid.org/0000-0003-0033-2454
Büşra Saraçoğlu
Institute of Science and Technology, Kocaeli University, Kocaeli, Türkiye
https://orcid.org/0000-0003-1814-5753
Arif Özkan
Department of Biomedical Engineering, Kocaeli University, Kocaeli, Türkiye
https://orcid.org/0000-0002-1288-6166
Yasin İlhan
Institute of Science and Technology, Kocaeli University, Kocaeli, Türkiye
https://orcid.org/0000-0001-8671-6250

Abstract

Hard tissues in the human body are damaged due to age, trauma, and bone diseases. Metal implants/prostheses are traditionally preferred to repair and treat these damaged tissues. Today, metals and their alloys meet the mechanical requirements of the musculoskeletal system well. However, the need to develop alternative composite materials has increased since metals are very stiff materials compared to bone. Problems such as stress shielding, and aseptic loosening can arise due to their high modulus of elasticity, and the need for secondary revision operations for such reasons. Also, the metal implant/prostheses should be removed after the healing that causes the undesirable secondary operation. In this study, polylactic acid (PLA) and hydroxyapatite (HA)-based composite materials were produced and their mechanical characteristics evaluated for possible implant applications. In addition, the PLA/HA composite materials stayed in Artificial Body Fluid (ABF) at different times, and the change in the mechanical properties were determined. PLA granules and HA powders were mixed in different ratios of weight (weight ratio 1:0, 9:1, 7:3, and 1:1) to produce 80 samples using the solvent casting technique. PLA was dissolved with chloroform in a magnetic stirrer at 200 rpm and room temperature, and then nano HA was added and mixed until homogeneity was achieved. After casting and drying, the samples were cut into appropriate standard sizes. The samples were subjected to biodegradability in-vitro test. In the results of this study, the modulus of elasticity increased with the increase of HA in the samples; however, the yield strength, ultimate strength, and yield strain of the samples decreased. In addition, it was observed that the existence of HA decreases the rate of degradation; therefore, the percentage of weakening in mechanical strength decreased in the measurements made at the end of the 15th day. According to these results, it was concluded that PLA/HA biodegradable composites can be developed to use as implant/prosthesis material.

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite
Çelik, T., Saraçoğlu, B., Özkan, A., & İlhan, Y. (2023). Biodegradable Pla/Ha Composite Material Production and Mechanical Characterization for Temporary Implant Applications. International Journal of Pioneering Technology and Engineering, 2(02), 188–192. https://doi.org/10.56158/jpte.2023.59.2.02

References

  1. Katarivas Levy, G., Goldman, J., & Aghion, E. “The prospects of zinc as a structural material for biodegradable implants—a review paper.” Metals, 7(10), 402,2017
  2. Güner, A. T., & Meran, C. “Biomaterials used in orthopedic implants.” Pamukkale University Journal of Engineering Sciences-Pamukkale, 6:1:54-67,2020.
  3. Çelik, T., Mutlu, İ., Özkan, A., & Kişioğlu, Y. “The effect of cement on hip stem fixation: a biomechanical study.” Australasian physical & engineering sciences in medicine, 40, 349-357,2017
  4. Çelik, T., & Kişioğlu, Y. “Evaluation of new hip prosthesis design with finite element analysis.” Australasian physical & engineering sciences in medicine, 42(4), 1033-1038,2019.
  5. Black J. “Biological Performance of Materials Fundamentals of Biocompatibility.” 4th ed. New York: Marcel Dekker; 1999.
  6. Anand, N., & Pal, K. “Evaluation of biodegradable Zn–1Mg–1Mn and Zn–1Mg–1Mn-1HA composites with a polymer-ceramics coating of PLA/HA/TiO2 for orthopaedic applications.” Journal of the Mechanical Behavior of Biomedical Materials, 136:1751-6161,2022
  7. Vojtěch, D., Kubásek, J., Šerák, J., & Novák, P. “Mechanical and corrosion properties of newly developed biodegradable Zn-based alloys for bone fixation.” Acta biomaterialia, 7(9), 3515-3522,2011.
  8. Chakraborty Banerjee, P., Al-Saadi, S., Choudhary, L., Harandi, S. E., & Singh, R. “Magnesium implants: Prospects and challenges.” Materials, 12(1), 136,2019.
  9. Çelik, T., Taşdemirci, Ç., Mutlu, İ., & Özkan, A. “Evaluation of the Use of PLA Material for Pedicle Screws in Terms of Strength.” Afyon Kocatepe University Journal of Science and Engineering, 21(4), 996-1004,2021.
  10. Özcan İ, “Construction of a Functional Biodegradable Bone Tissue Engineering Scaffold for Enhanced Biomineralization,”, İstanbul Technical University, Institu of Science, 4-5, 13-14 Doctoral Thesis,2016.
  11. Farah S, Anderson DG, Langer R. “Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review.” Advanced drug delivery reviews, 15:107:367-392,2016.
  12. Zhang B, Wang L, Song P, Pei X, Sun H, Wu L, Zhang X. 3D “Printed Bone Tissue Regenerative PLA/HA Scaffolds with Comprehensive Performance Optimizations.” Materials and Design , 201:109490, 2021.
  13. Ko HS, Lee S, Lee D, Jho JY. “Mechanical Properties and Bioactivity of Poly(Lactic Acid) Composites Containing Poly(Glycolic Acid) Fiber and Hydroxyapatite Particles.” Nanomaterials, 11, 249, 2021
  14. Kokubo T, Takadama H. “How useful is SBF in Predicting In Vivo Bone Bioactivity?” Biomaterials, 27:15:2907-2915,2006.
  15. [15] Demirkol N. “Production and Characterization of Sheep Hydroxyapatite Composites.” İstanbul Technical University, Institu of Science, 335822,2013, Doctoral Thesis.
  16. Kim SJ, Park HS, Lee DW, Lee JW. “Short-term daily teriparatide improve postoperative functional outcome and fracture healing in unstable intertrochanteric fractures.” Injury, 50:7:1364-1370,2019.
  17. Ridzwan MIZ, Shuib S, Hassan AY, Shokri AA, Ibrahim MM. “Problem of stress shielding and improvement to the hip implant designs: a review.” J Med Sci ;7:460–467,2007.
  18. Chen WP, Tai CL, Lee MS, Lee PC, Liu CP, Shih CH. “Comparison of stress shielding among different cement fixation modes of femoral stem in total hip arthroplasty-a three-dimensional finite element analysis”. J Med Biol Eng,24:183–187,2004.
  19. Kannan R, Wei G, Ma PX. “Synthetic Polymeric Biomaterials for Tissue Engineering.” Tissue Engineering Using Ceramics and Polymers,41–74,2022.
  20. Pina S, Reis RL, Oliveira JM. “Natural Polymeric Biomaterials for Tissue Engineering.” Tissue Engineering Using Ceramics and Polymers,75–110, 2022.
  21. Çelik, T, Mutlu İ, Özkan A. “The Strength of The Connection Types Used In 3-dimensional Printer Parts Produced Partially.” Int J 3D Printing Tech and Digital Industry;6:137-142,2022.
  22. Rincón-Kohli L, Zysset PK. “Multi-axial mechanical properties of human trabecular bone”. Biomech Model Mechanobiol 8:195-208,2009.
  23. Arslan, A. “Poly (butyleneadipate-co-terephthalate) (Pbat) Based Scaffolds: Synthesis, Characterization And Osteoblastic Activity”. Hacettepe University, Institu of Science, 2015;415220,2015, Master Thesis,.
  24. Freier T, Kunze C, Schmitz KP. “Solvent Removal from Solution-Cast Films of Biodegradable Polymers.” J Mater Sci Letters 20:1929-1931,2001.
  25. Marzuki AP, Salleh FM, Rosli MSN, Abdullah AH, Thrazi I, Halim NHA. “Rheological, Mechanical and Physical Properties of Poly-Lactic Acid (PLA)/ Hydroxyapatites (HA) Composites Prepared by an Injection Moulding Process.” J Mech Eng ,19:2:17-39,2022.
  26. Hong Z, Zhang P, He C, Qiu X, Liu A, Chen L, Chen X, Jing X.” Nano-composite of poly(L-lactide) and surface grafted hydroxyapatite: mechanical properties and biocompatibility.” Biomaterials., 26:32:6296-304,2005.